What is codeine, and what is it used for?
Codeine is a narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone.
Moreover, a small amount of codeine is converted to morphine in the body. The precise mechanism of action of codeine is not known; however, like morphine, codeine binds to receptors in the brain (opioid receptors) that are important for transmitting the sensation of pain throughout the body and brain.
Codeine increases tolerance to pain, decreasing discomfort, but the pain still is apparent to the patient. In addition to reducing pain, codeine also causes sedation drowsiness and depresses breathing. Codeine frequently is combined with acetaminophen (Tylenol) or aspirin for more effective pain relief.
The FDA approved codeine in 1950.
What are the side effects of codeine?
The most frequent side effects of codeine include:
- Lightheadedness
- Dizziness
- Nausea
- Vomiting
- Shortness of breath
- Sedation
- Allergic reactions
- Constipation
- Abdominal pain
- Rash
- Itching
Serious side effects of codeine include:
- Life-threatening respiratory depression
- Severe low blood pressure
- Adrenal insufficiency
- Accidental ingestion of codeine can result in fatal overdose
Is codeine addictive? Is it a controlled substance?
- Codeine is habit forming (addictive). Mental and physical dependence can occur but are unlikely when used for short-term pain relief. Using codeine during pregnancy can cause opioid withdrawal syndrome in the newborn, which may be life-threatening if not treated.
- If codeine is suddenly withdrawn after prolonged use, symptoms of withdrawal may develop. The dose of codeine should be reduced gradually in order to avoid withdrawal symptoms.
![](https://images.medicinenet.com/images/quiz/pain/pain-s2.jpg)
QUESTION
Medically speaking, the term "myalgia" refers to what type of pain? See AnswerCan I drink alcohol with codeine? What other drugs interact with codeine?
- Codeine can impair thinking and physical abilities required for driving or operating machinery.
- Alcohol and other sedatives such as alprazolam (Xanax) can produce further brain impairment and even confusion when combined with codeine. Therefore, alcohol and other sedatives should not be used when taking codeine.
- Drugs that stimulate and also block opioid receptors (for example, pentazocine) reduce the effect of codeine. Such drugs should not be combined with codeine.
- Drugs that block the action of acetylcholine (anticholinergic drugs) increase the occurrence of urinary retention and constipation when combined with codeine.
- Monoamine oxidase inhibitors (MAOIs) class of antidepressants (for example, isocarboxazid [Marplan], phenelzine [Nardil], tranylcypromine [Parnate], selegiline [Eldepryl], and procarbazine [Matulane]) significantly increase the action of codeine. Codeine should not be used in patients taking MAOIs or within 14 days of stopping MAOIs.
What is the dosage for codeine?
Is it safe to take codeine if I am pregnant or breastfeeding?
- Small amounts of codeine are secreted in breast milk, but the risk of adverse events in the infant is small.
Summary
Codeine is a narcotic pain reliever (analgesic) used to treat mild to moderately severe pain. It is frequently combined with Tylenol or aspirin for more effective pain relief. Common side effects include itching, rash, stomach pain, constipation, shortness of breath, nausea, lightheadedness, and dizziness. More serious adverse effects codeine are severe low blood pressure and adrenal insufficiency. Codeine is a controlled narcotic and it has the potential for abuse. Dependence and addiction can occur with codeine, even at prescribed dosages when taken over long periods.
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Treatment & Diagnosis
- Lower Back Pain
- Torn ACL (Anterior Cruciate Ligament Tear)
- Cold Fingers
- Dengue Fever
- Tylenol Liver Damage
- Chronic Pain
- Bone Cancer
- Doctor: Checklist to Take To Your Doctor's Appointment
- Pain Management
- Pain Management: Routes to Relief
- Pain Management: Painkiller Addiction
- Pain Awareness and Management
- Pain Management: Dealing with Back Pain
- Headaches FAQs
- Back Pain FAQs
- Pain FAQs
- Prescription Drug Abuse
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Tylenol Toxicity
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Pain (Acute and Chronic)
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Medications & Supplements
- acetaminophen - oral, Panadol, Tylenol
- codeine phosphate - injection
- codeine/carisoprodol/aspirin - oral, Soma Compound with Codeine
- codeine/butalbital/aspirin/caffeine - oral, Fiorinal with Codeine #3
- promethazine/phenylephrine/codeine - oral
- acetaminophen/codeine - oral, Tylenol-Codeine No.3, Tylenol-
- promethazine/codeine syrup - oral, Phenergan w/ codeine
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- aspirin
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- hydrocodone/acetaminophen
- fentanyl patch (Duragesic)
- montelukast, Singulair
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- terpin hydrate/codeine
- promethazine and codeine, Phenergan with Codeine
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- OTC Pain Relievers and Fever Reducers
- Side Effects of Norflex (orphenadrine)
- Cold Medicine and Cough Syrup for Adults
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- oxymorphone
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- metaxalone
- Pain Medications (Narcotics)
Prevention & Wellness
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.